We have developed novel 3D tissue models that accurately reflect the biology and function of human liver. Furthermore, we ANALYZED the pharmacogenomic landscape in 130,000 individuals and found that previously unappreciated rare genetic variants in drug metabolizing enzymes and transporters contribute 30-40% to differ inter-individual differences in drug response.Read more
Erik Norberg was awarded a 2.3 million SEK project grant from Cancerfonden and a 6-year Young Investigator position from the same foundation. These grants are a direct continuation of his previous work supported focusing on understanding the metabolic regulation in cancer.
Our main goal of this study was to determine the functional role of distinct utilization of serine metabolism to lung adenocarcinomas. We identified a metabolic subtype, described by PHGDH, with poor prognosis that display with unique metabolic dependencies (Zhang et al. Cell Reports, 2017).Read more
"Human Rights and Community-led Development ,Lessons from Tostan" by Ben Cislaghi recommends Tostan as a best practice for ethical and effective development. The book is published by Edinburgh University Press. Ben Cislaghi is an Assistant Professor in Social Norms at the London School of Hygiene and Tropical Medicine (Centre for Gender, Health and Violence).Read more
Maria Ulvmar has been awarded the starting grant from the The Swedish Research Council (VR) 2016. The aim of the 4-year grant of 1.5 million per year (6 million SEK in total), is to support junior researchers to become established as independent group leaders. Read more
In a recent study we discovered that a rare lipid in the outer membrane of b-cells plays a critical role in regulating the amount of calcium that enters the b-cell and, in extension, also the amount of insulin that these cells release. Experimental removal of this lipid by an optogenetic approach almost completely abolished calcium entry and strongly suppressed insulin release. Read more
Erik Norberg has been awarded with a 3-year grant from the Swedish Society for Medical Research (SSMF). The grant is 3 million SEK and was awarded to 4 researchers in the medical field of research in Sweden.