The Molecular & Cellular Exercise Physiology Group

Our laboratory is located at the Karolinska Institutet’s Solna campus in the Department of Physiology and Pharmacology. 

The common goal of the projects we are developing is to better understand the signal transduction and gene regulatory pathways that control local and systemic adaptations to physical exercise. 

One of today's greatest challenges in research and health care is to preserve the health and quality of life of an ageing population. Several lines of research have shown a clear association between a sedentary behavior and the incidence of several debilitating diseases including diabetes, obesity, cardiovascular disease, neurodegenerative diseases (such as Alzheimer’s and Parkinson’s), mood disorders (e.g. depression), and even cancer. 

Physical activity and skeletal muscle condition play a clear role in the prevention and treatment of these diseases. However, exercise programs are not always viable treatment options due to inherent disease characteristics such as muscle weakness, difficulty in movement, or, in particular, patient compliance. By studying the mechanisms by which skeletal muscle adapts to different challenges and positively affects so many aspects of human health, we can learn valuable lessons that can be translated into future disease therapies. 

You can read more about us at  www.ki.se/research/jorgeruas